ASTROCYTE MATRICELLULAR PROTEINS THAT CONTROL EXCITATORY SYNAPTOGENESIS ARE REGULATED BY INFLAMMATORY CYTOKINES AND CORRELATE WITH PARALYSIS SEVERITY DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

The matricellular proteins, secreted protein acidic and rich in cysteine (SPARC) and SPARC-like 1 (SPARCL1), are produced by astrocytes and control excitatory synaptogenesis in the central nervous system.While SPARCL1 directly promotes excitatory synapse formation in vitro and in the developing nervous system in vivo, SPARC specifically antagonizes

BackgroundPerceived as a minor transportation mode mainly for recreation, cycling and its related safety issues have not been treated as a citywide concern in Hong Kong and have thus received inadequate research efforts.Our study aimed to illuminate the safety challenges faced by Light Therapy Lamps cyclists in Hong Kong.MethodsWe examined the poli

Kocher-Debre-Semelaigne (KDS) syndrome is a rare form of hypothyroid myopathy, Airstones with associated hypertrophy of muscles.Although cardiac manifestations of hypothyroidism are well known, reports of cardiac involvement in KDS have only described the occurrence of pericardial BEST LIFT FPX 600 EM External Concealed Hood effusion as an associat

Abstract Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported in experimentally induced colitis via a macrophage-dependent process.The aim of this study is to reveal how myenteric barrier disruption and subsequent neuronal injury affects gut motility in vivo in a murine colitis model.We induced colitis with d